• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    This invention relates to a process to improve the feed efficiency and carcass characteristics of an animal. The process of this invention can be used to decrease the cost of animal diets, to improve performance of animals and to improve the percentage of carcass in animals.
    公开号:AU2013222795A1
    申请号:U2013222795
    申请日:2013-02-21
    公开日:2014-09-18
    发明作者:Joan Torrent Campmany
    申请人:CAMPMANY JOAN；
    IPC主号:A61K31-58
    专利说明:
    WO 2013/126149 PCT/US2013/000048 5 10 PROCESS TO IMPROVE FEED EFFICIENCY AND CARCASS CHARACTERISTICS OF ANIMALS TECHNICAL FIELD This invention relates to a process that improves the feed efficiency of animals. The 15 process of this invention can be used to improve the feed efficiency of many types of animals and, therefore, is useful to decrease feed costs for animals and also as a growth promoter or enhancer. 20 BACKGROUND OF THE INVENTION The cost of feeding an animal is estimated to be approximately 70% of the total cost of the production of that -animal. Therefore, ways to decrease these feeding costs can have a very important effect on the final cost of animal products, such as meat, milk, eggs and wool. 25 Animals use the energy extracted from the feed for different purposes. A principal purpose is referred to as "maintenance". The energy for maintenance is used by the animals to maintain life. If the feed does not provide enough energy for maintenance, animals lose weight as they have to use their body reserves to survive. Once maintenance requirements - I - WO 2013/126149 PCT/US2013/000048 5 have been met, the rest of the energy can be used for growth (for example, meat, milk, eggs and wool) or reproduction. There are two classical ways to increase the amount of energy that animals are able to extract from feed and, therefore, to improve their energy and/or feed efficiency. One is to increase the energy in the feed, and the other is to change the energy metabolism of the 10 animal to make their metabolism more efficient. Enzymes increase the energy of the feed. The idea behind the use of enzymes is that enzymes degrade compounds that are undigestible or have antinutritional properties. This degradation allows the animal to extract more energy from the feed. Typical examples of enzymes are pentosanases, beta-glucanases or phytases used to degrade pentosans (found in 15 wheat), beta-glucans (found in barley) or phytates (found in vegetable ingredients), respectively. Antibiotics change the way energy is used by the animal. The exact way that antibiotics increase the energy available for the animal is not clearly understood. However, 20 antibiotics have been related to a decrease in the amount of energy needed by the animal to fight pathogens. Antibiotics would keep the microbial challenge low and, as a result, less energy would be allocated to the immune system to fight those pathogens. This savings in energy can then be used for production. Therefore, antibiotics would not increase the energy density of the feed, but would decrease the maintenance requirements of the animal. 25 with the net result being more energy available for production. -2- WO 2013/126149 PCT/US2013/000048 5 New regulatory measures are constraining the use of antibiotics as growth promoters in many countries. In 2006, the European Union forbade the use of antibiotics as growth promoters, and the FDA is studying limitations on the use of antibiotics in the U.S.. Hormones are examples of other products that change the way energy is used by animals by changing where that energy is directed. For example, the hormone somatotropin 10 increases the amount of energy allocated to milk production instead of meat production. '[he hormone ractopamine increases the amount of lean tissue which correspondingly decreases the amount of fat tissue. The use of hormones and antibiotics in animal production is facing a strong opposition by public opinion due to possible residues of these materials in animal products. 15 Therefore, products that could improve feed and energy efficiency that are not hormones or antibiotics have a very attractive market. U.S. Patent Application Publication No. US 2008/0226760 discloses a composition which is useful in the process of this invention. However, that composition is disclosed as having antimicrobial activity; that is, when animals have a microbial challenge. 20 In the process of this invention, the composition disclosed in U.S. Patent Application Publication No. US 2008/0226760 is shown to improve feed efficiency for animals kept in situations free of microbial challenge. Therefore, the improved feed efficiency results from a change in the use of energy from feed, not from a decrease in the microbial challenge. -3 - WO 2013/126149 PCT/US2013/000048 5 The present invention shows that the improved energy efficiency of animals treated with this composition occurs when the animals are kept in situations free of microbial challenge. Therefore, the improved energy efficiency is not caused by the decrease in microbial challenge or the lower amount of energy used by the immune system, but by changes in the use of energy. Thus, in the present invention, a process has been developed: 10 to improve the energy efficiency of animals; to improve the carcass characteristics of animals; to decrease the cost of feeding animals; to not leave residues in the meat, milk, eggs, wool or other products of animals. 15 SUMMARY OF THE INVENTION Briefly described, this invention provides a process that can be used to improve the feed efficiency and carcass characteristics of animals. This process can be used in foods for various types of animals. This process does not leave toxic residues in food or in the carcass 20 of animals. There are no known adverse or side effects of animals treated by the process of this invention, which can be used during the life of the animals. These and other features and advantages of this invention will become apparent from the following detailed description. 25 -4- WO 2013/126149 PCT/US2013/000048 5 DETAILED DESCRIPTION OF THE INVENTION In accordance with this invention, a process is provided in which an animal is treated with a composition which comprises: A. from about 2.0 to about 76.0 percent by weight of at least one triglyceride containing at least one hydroxylated fatty acid having from about 10 to about 20 carbon 10 atoms in its chain and B. from about 24.0 to about 95.0 percent by weight of cashew nut shell liquid or a compound selected from the group consisting of cardol, cardanol, anacardic acid and salts of anacardic acid, wherein the feed efficiency and carcass characteristics of the animal are 15 improved in comparison to the animal before treatment. Ricinoleic acid has been shown to have antimicrobial (Novak et al, 196 1,. Amer. Oil Chem. Soc. 38:321-324) and anti-inflammatory (Vieira et al., 2001, Naunyn-Schmiedeberg's Arch. Pharmacol., 364 :87-95) activities, but an effect on the energy usage or feed efficiency of an animal has not been reported. 20 The liquid from the cashew nut shell and its components have been shown to have multiple activities, such as antimicrobial (Eichbaum, 1946, Mem. Inst. Butantan, 19:71-96; Gellerman et al., 1969, Can. J. Microbiol. 15: 1219-1223) and antioxidant (Trevisan ct al.. 2006, Food Tech. Toxicol. 44(2):188-97), as well as inhibition of the enzymes alpha glucosidase, invertase and aldose reductase (Toyomizu et al., 1993, Phytotherapy 7, 252 25 254). However, an effect on the energy efficiency of an animal has not been reported. -5 - WO 2013/126149 PCT/US2013/000048 5 The effects of one of the components of the cashew nut shell liquid on feed efficiency of animals was done in rats supplemented with anacardic acid and showed no differences between supplemented and non-supplemented animals (Toyomizu et al., 2003, Anim. Sci. J. 74: 499-504). As defined above, the process of this invention utilizes a composition having 2 10 essential components, the first of which is at least one triglyceride containing at least one hydroxlated fatty acid which has from about 10 to about 20 carbon atoms in its chain. This component is used in an amount of about 2.0 to about 76.0 percent by weight based on the weight of the composition, preferably about 10.0 to about 30.0 percent by weight. As used in this application, the term "weight percent" or "percent by weight" is based 15 on the weight of the total composition. Examples of triglycerides for use in this process include castor oil and bladderpod oil. The preferred triglyceride is castor oil. The composition may contain a blend of two or more triglycerides. Preferred hydroxylated fatty acids include ricinoleic acid, hydroxystearic acid and 20 lesquerolic acid. The triglyceride may contain more than one hydroxylated fatty acid. The second essential component is the cashew nut shell liquid (that is, the liquid derived from the cashew nut shell) or at least one compound derived from the cashew nut shell liquid. These compounds (also referred to as cashew nut shell compounds) are cardol. cardanol, anacardic acid and salts of anacardic acid. The composition may contain more 25 than one cashew nut shell compound. This component is used in an amount of about 24.0 to about 95.0 percent by weight based on the weight of the composition, preferably about 30.0 -6- WO 2013/126149 PCT/US2013/000048 5 to about 80.0 percent by weight. Examples of anacardic acid salts which can be used in the process of this invention are the zinc and copper salts. Preferably, the ratio of triglyceride: cashew nut shell component (whether the liquid or one or more compounds) is from about 1:4 to about 1:2, most preferably 1:3.3. 10 This invention provides a process that improves the feed efficiency and carcass characteristics of an animal independently of the antimicrobial activity of the animal. This invention has shown beneficial effects when animals were in situations where no microbial challenge was taking place, and/or when compared to animals fed antimicrobial compounds. Although not clearly understood, the advantages of this process are believed to result 15 from a decrease in the maintenance requirements of the animal through a decrease in the visceral organ mass of the treated animals. Visceral organs (such as the liver and intestines) are highly active and use a lot of energy. A process that decreases the energy used by the visceral organs, either through a decrease in organ size or energy use, frees more energy for growth or the production of products (such as meat, milk, eggs and wool). The decrease in 20 visceral organ mass also results in improvements of the carcass characteristics, as the percentage of saleable meat in proportion to the total weight of the animal is increased. resulting in an improvement of the economic value of the treated animal. The compositions for use in this process may be applied directly, or through solid and liquid carriers, to facilitate the application of the composition. Appropriate carriers are those 25 that do not interfere with the release of the essential components. -7- WO 2013/126149 PCT/US2013/000048 5 The administration of the composition will vary in accordance to the user's objective. However, the dose must be between about 10 and about 10,000 ppm, in proportion to the total (or complete) animal feed ingested by the animal or offered to the animal. A preferred dose is from about 250 to about 2,000 ppm. In the process of this invention, the composition is added to the animal feed. Stated 10 another way, the animal feed is supplemented by the composition. The composition does not replace the animal feed. Other components can be used in the composition to achieve various effects and/or to enhance the performance of the process. Examples of such optional components include carriers, thickening agents, preservatives, perfumes, stabilizing agents, organic acids and 15 emulsifiers. If used, these components are used in amounts necessary to achieve their purpose, but not in amounts which would adversely affect the process. Examples of such optional components are expanded vermiculite, fats, ethanol. glycerol and propylene glycol. Examples of organic acids which can be used in the process of this invention are 20 short chain acids (such as formic, lactic, acetic, propionic, butyric, malic and citric) and medium chain acids (such as caprylic, capric, caproic and lauric). The present invention is further illustrated by the following examples which are illustrative of certain embodiments designed to teach those of ordinary skill in the art how to practice this invention and to represent the best mode for carrying out this invention. 25 -8- WO 2013/126149 PCT/US2013/000048 5 EXAMPLE 1 Five animals from each one of 14 bird houses (seven control and seven treated by this process) between 17 and 22 days of age were sacrificed and the live weight and the weight of the livers and the intestines were taken and compared using an analysis of variance correcting for the age of the birds. The composition was 40% cashew nut shell 10 liquid, 12% castor oil and 48% expanded vermiculite. The birds were fed a commercial diet following industry standards. The only difference between the two groups was the supplementation of 0.15% of the composition in the feed. Table 1 Item Control Composition Difference, % Body Weight, g 709 737 4 Liver, g 26.10 23.25 11 Liver, in % of weight" 3.73 3.17 15 Intestine, gb 1 51.25 1 48.25 6 Intestine, in % of weight 7.44 6.60 11 'Treatments differ P <0.05. 15 bTreatments differ P = 0.075. Table 1 shows that the weight of the intestines and liver as a percentage of total weight was lower for the birds treated by this process. The strength of the data can be checked through the P values. In statistics, a P value tells us the chances that 20 differences attributed to a treatment are actually not due to that treatment but to random variation. In this case, there is less than a 5% chance (P < 0.05) that the differences in visceral organ mass (liver and intestines) are not due to the process. As the weight of the visceral organs is lower in the treated animals, the weight of the carcass has to be larger and, therefore, there is more saleable meat. -9- WO 2013/126149 PCT/US2013/000048 5 Although one could argue that the treated animals had smaller intestines because of the antimicrobial activity of the composition (a decrease in the microbial challenge results in a decrease of the thickness of the intestines), the weights of the liver are not affected by the antimicrobial activity of the composition as the liver is not directly in contact with the microorganisms as happens with the intestines. 10 In conclusion, the supplementation of the composition decreased visceral organ mass and, therefore, decreased energy requirements and improved the carcass characteristics of the birds. EXAMPLE 2 15 One hundred and ninety four one day old chicks were divided into two groups. One group was treated with 0.15% of the composition that was 40% cashew nut shell liquid, 12% castor oil and 48% expanded vermiculite, and the other group was used as a control. Each group was divided into 9 repetitions with 33 birds in each repetition. Both groups were fed a diet meeting industry standards, with the only difference between both groups 20 being supplementation of 0.15% of the composition in the feed. To obtain the apparent metabolizable energy (AME) of the diets, the birds were put in cages and the feces and urine were collected from day 20 to 25. Unlike birds that are on the ground, birds in cages are not challenged by microorganisms, as feces and urine are collected and do not stay in contact with the birds causing pathogenic challenges. Therefore, 25 any increase in AME is due to either a better digestion or to a decrease in maintenance energy requirements. -10- WO 2013/126149 PCT/US2013/000048 5 Table 2 Diet with Composition Control Diet Difference AME (Kcal/kg)a 2,881 2,777 4% AMEn (kcal/kg)a 2,568 2,449 5% FCb 1.772 .1.806 2% AMEn = Nitrogen corrected metabolizable energy FC = Feed conversion (Kg of ingested food/Kg of weight gain) "Treatments differ (P < 0.06) bTreatments differ (P = 0.08) 10 Again, as in Example 1, the strength of the data can be checked through the statistics. There is only a 6% chance that the difference in apparent metabolizable energy is not due to the supplementation of the composition, and an 8% chance that the difference in feed conversion is not due to the treatments. 15 It is important to observe that the increase in energy of the diet in Example 2 is very similar to the increase in weight of the animals of Example 1. A 4% increase in energy is actually higher than what is expected from conventional growth promoters. The industry standard for antibiotic growth promoters is around 2% increase in energy of the diets, which is exactly the improvement observed in feed conversion. 20 In conclusion, the composition increased the amount of energy efficiency and the feed conversion of the treated animals. 25 - 11 - WO 2013/126149 PCT/US2013/000048 5 EXAMPLE3 Forty eight steers with an initial average weight of 322 kg were divided into two groups and fed until each steer reached 617 kg of live weight. The two groups were treated with Monensin (223 mg/head/day) and the Composition (500 ppm in total feed). Monensin 10 is the antibiotic used in the industry as a standard to affect microbial populations in the rumen of the animals. The change in microbial populations in the rumen shifts the fermentation end products, which results in an improvement in the energy efficiency of the animal. By comparing the Composition to the industry standard, the effects due to changes in microbial populations can be deleted. Therefore, if differences were found between 15 Monensin treated animals and the Composition treated animals, those differences would not arise from the antimicrobial effects, as both products inhibit the same type of bacteria (grain positive). The Composition was 40% cashew nut shell liquid, 12% castor oil and 48% expanded vermiculite. Table 3 Monensin Composition Dressing percent 60a 62b Carcass quality grade 3.18a 4.04b 20 abTreatments with different superscripts differ (P < 0.05) Dressing percent is the percentage of the carcass in relation to the total weight of the animal. Carcass quality grade goes from I to 9 to indicate, in increasing order, the amount of intramuscular fat. Meats with higher levels of intramuscular fat are more tender and. 25 therefore, more expensive. Also, as the amount of energy found per unit of fat is twice as - 12 - WO 2013/126149 PCT/US2013/000048 5 much as the amount of energy found per unit of carbohydrate and around 40% more than the amount of energy found per unit of protein, meats with more intramuscular fat are more energy dense than leaner meats. Therefore, at equal weights, animals with more intramuscular fat must have been more energy efficient to be able to have more energy dense muscles. 10 The data in Table 3 shows that the Composition not only increased the amount of carcass, but that the carcass was also more energy dense. In conclusion, the supplementation of the composition increased the energy density of the diet as well as improved the carcass characteristics of the animals. Therefore, the process of this invention is useful to improve the energy/feed 15 efficiency of the animals and to improve carcass characteristics of animals. This invention has been described in detail with particular reference to certain embodiments, but variations and modifications can be made without departing from the. spirit and scope of the invention as defined in the following claims. 20 25 - 13 -
    权利要求:
    Claims (33)
    [1] 1. A process to improve the feed efficiency and carcass characteristics of an animal, wherein the process comprises orally treating the animal with a composition which comprises: A. from about 2.0 to about 76.0 percent by weight of at Icast one 10 triglyceride containing at least one hydroxylated fatty acid having from about 10 to about 20 carbon atoms in its chain and B. from about 24.0 to about 95.0 percent by weight of cashew nut shell liquid or a compound selected from the group consisting of cardol, cardanol, anacardic acid and salts of anacardic acid, 15 wherein the feed efficiency and carcass characteristics of the animal are improved in comparison to the animal before treatment.
    [2] 2. A process as defined by Claim 1, wherein the hydroxylated fatty acid is ricinoleic acid, hydroxystearic acid or a blend of such compounds. 20
    [3] 3. A process as defined by Claim 1, wherein the hydroxylated fatty acid is ricinoleic acid.
    [4] 4. A process as defined by Claim 1, wherein the hydroxylated fatty acid is 25 hydroxystearic acid. -14- WO 2013/126149 PCT/US2013/000048 5
    [5] 5. A process as defined by Claim 1, wherein the triglyceride contains ricinoleic acid.
    [6] 6. A process as defined by Claim 1, wherein the triglyceride contains hydroxystearic acid. 10
    [7] 7. A process as defined by Claim 1, wherein the triglyceride is castor oil.
    [8] 8. A process as defined by Claim 1, wherein the cashew nut shell compound is cardol. 15
    [9] 9. A process as defined by Claim 1, wherein the cashew nut shell compound is cardanol.
    [10] 10. A process as defined by Claim 1, wherein the cashew nut shell compound is anacardic acid. 20
    [11] 11. A process as defined by Claim 1, wherein the cashew nut shell compound is a salt of anacardic acid. - 15 - WO 2013/126149 PCT/US2013/000048 5
    [12] 12. A process as to improve the feed efficiency and carcass characteristics of an animal, wherein the process comprises orally treating the animal with a composition which comprises: A. from about 2.0 to about 76.0 percent by weight of at least one triglyceride containing at least one hydroxylated fatty acid having from about 10 to about 20 10 carbon atoms in its chain and B. from about 24.0 to about 95.0 percent by weight of cashew nut shell liquid or a compound selected from the group consisting of cardol, cardanol. anacardic acid and salts of anacardic acid, wherein the feed efficiency and carcass characteristics of the animal are 15 improved in comparison to the animal before treatment and wherein the ratio of component A: component B is from about 1:4 to about 1:2.
    [13] 13. A process as defined by Claim 12, wherein the hydroxylated fatty acid is ricinoleic acid, hydroxystearic acid, or a blend of such compounds. 20
    [14] 14. A process as defined by Claim 12, wherein the hydroxylated fatty acid is ricinoleic acid.
    [15] 15. A process as defined by Claim 12, wherein the hydroxylated fatty acid is 25 hydroxystearic acid.
    [16] - 16- WO 2013/126149 PCT/US2013/000048 5 16. A process as defined by Claim 12, wherein the triglyceride contains ricinoleic acid.
    [17] 17. A process as defined by Claim 12, wherein the triglyceride contains hydroxystearic acid. 10
    [18] 18. A process as defined by Claim 12, wherein the triglyceride is castor oil.
    [19] 19. A process as defined by Claim 12, wherein the cashew nut shell compound is cardol. 15
    [20] 20. A process as defined by Claim 12, wherein the cashew nut shell compound is cardanol.
    [21] 21. A process as defined by Claim 12, wherein the cashew nut shell compound is 20 anacardic acid.
    [22] 22. A process as defined by Claim 12, wherein the cashew nut shell compound is a salt of anacardic acid. -17- WO 2013/126149 PCT/US2013/000048 -5
    [23] 23. A process to improve the feed efficiency and carcass characteristics of an animal, wherein the process comprises orally treating the animal with a composition which comprises: A. from about 2.0 to about 76.0 percent by weight of at least one triglyceride containifig at least one hydroxylated fatty acid having from about 10 to about 20 10 carbon atoms in its chain and B. from about 24.0 to about 95.0 percent by weight of cashew nut shell liquid or a compound selected from the group consisting of cardol, cardanol, anacardic acid and salts of anacardic acid, wherein the feed efficiency and carcass characteristics of the animal are 15 improved in comparison to the animal before treatment and wherein the composition is present in an amount of about 10 to about 10,000 parts per million of the feed.
    [24] 24. A process as defined by Claim 23, wherein the hydroxylated fatty acid is ricinoleic acid, hydroxystearic acid or a blend of such compounds. 20
    [25] 25. A process as defined by Claim 23, wherein the hydroxylated ntty acid is ricinoleic acid.
    [26] 26. A process as defined by Claim 23, wherein the hydroxylated fatty acid is 25 hydroxystearic acid. -.18 - WO 2013/126149 PCT/US2013/000048 5
    [27] 27. A process as defined by Claim 23, wherein the triglyceride contains ricinoleic acid.
    [28] 28. A process as defined by Claim 23, wherein the triglyceride contains hydroxystearic acid. 10
    [29] 29. A process as defined by Claim 23, wherein the triglyceride is castor oil.
    [30] 30. A process as defined by Claim 23, wherein the cashew nut shell compound is cardol. 15
    [31] 31. A process as defined by Claim 23, wherein the cashew nut shell compound is cardanol.
    [32] 32. A process as defined by Claim 23, wherein the cashew nut shell compound is 20 anacardic acid.
    [33] 33. A process as defined by Claim 23, wherein the cashew nut shell compound is a salt of anacardic acid. 25 - 19-
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    同族专利:
    公开号 | 公开日
    WO2013126149A1|2013-08-29|
    CL2014002244A1|2015-04-10|
    MX2014010222A|2015-07-06|
    PE20142247A1|2014-12-27|
    BR112014020782A2|2020-10-27|
    MY180916A|2020-12-12|
    ZA201405510B|2016-06-29|
    CN104203248A|2014-12-10|
    HK1204270A1|2015-11-13|
    SG11201404591QA|2014-09-26|
    EP2819678B1|2018-11-07|
    CA2862938A1|2013-08-29|
    JP2015509367A|2015-03-30|
    AU2013222795B2|2015-12-24|
    EP2819678A4|2016-02-17|
    CA2862938C|2019-08-20|
    KR20140127899A|2014-11-04|
    KR102069910B1|2020-01-23|
    JP6092899B2|2017-03-08|
    EP2819678A1|2015-01-07|
    IN2014MN01497A|2015-04-17|
    US20130224320A1|2013-08-29|
    ES2710401T3|2019-04-24|
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    法律状态:
    2016-04-21| FGA| Letters patent sealed or granted (standard patent)|
    2021-09-16| MK14| Patent ceased section 143(a) (annual fees not paid) or expired|
    优先权:
    申请号 | 申请日 | 专利标题
    US13/385,521||2012-02-23||
    US13/385,521|US20130224320A1|2012-02-23|2012-02-23|Process to improve feed efficiency and carcass characteristics of animals|
    PCT/US2013/000048|WO2013126149A1|2012-02-23|2013-02-21|Process to improve feed efficiency and carcass characteristics of animals|
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